Author: Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Chan, Chris Chung-Sing; Yip, Cyril Chik-Yan; Mak, Winger Wing-Nga; Zhu, Houshun; Poon, Vincent Kwok-Man; Tee, Kah-Meng; Zhu, Zheng; Cai, Jian-Piao; Tsang, Jessica Oi-Ling; Chik, Kenn Ka-Heng; Yin, Feifei; Chan, Kwok-Hung; Kok, Kin-Hang; Jin, Dong-Yan; Au-Yeung, Rex Kwok-Him; Yuen, Kwok-Yung
Title: Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons Document date: 2016_11_12
ID: v4r5d26a_25
Snippet: The dexamethasone-immunosuppressed mice with ZIKV inoculation (groups 1 and 2) also had significantly lower mean viral loads in blood and most tissues at euthanasia at 12-14 dpi as compared with those collected at 5 dpi (↓ 1-4 log 10 copies/10 6 β-actin at 12-14 dpi) (Figs. 3A and B and S1A and B). At euthanasia (12-14 dpi), viral RNA was still detectable in most tissues of the male mice (up to 3 log 10 copies/10 6 β-actin), but viremia was a.....
Document: The dexamethasone-immunosuppressed mice with ZIKV inoculation (groups 1 and 2) also had significantly lower mean viral loads in blood and most tissues at euthanasia at 12-14 dpi as compared with those collected at 5 dpi (↓ 1-4 log 10 copies/10 6 β-actin at 12-14 dpi) (Figs. 3A and B and S1A and B). At euthanasia (12-14 dpi), viral RNA was still detectable in most tissues of the male mice (up to 3 log 10 copies/10 6 β-actin), but viremia was absent. The control mice with ZIKV inoculation but no dexamethasone immunosuppression had undetectable viral RNA in blood and most tissues, which was consistent with previous reports (Lazear et al., 2016; Dowall et al., 2016; Aliota et al., 2016; Rossi et al., 2016) . Overall, these findings were suggestive of multi-organ inflammation upon immune reconstitution with partial viral clearance in the mice after withdrawal of dexamethasone immunosuppression.
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