Author: Dawson, Patrick; Malik, Mamunur Rahman; Parvez, Faruque; Morse, Stephen S.
Title: What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review Document date: 2019_3_1
ID: yb54i1ne_17
Snippet: The virus readily replicates in A549 (human lung), Huh-7 (human liver), and the widely used Vero E6 (African green monkey kidney) cell lines , Eckerle et al. 2014 ), among others. Culture, in vitro and ex vivo, has also been used to help determine cell tropism and identify potential natural hosts of the virus. MERS-CoV can infect a variety of human cell types and tissues in culture, including macrophages, fibroblasts, and endothelial cells (Scobe.....
Document: The virus readily replicates in A549 (human lung), Huh-7 (human liver), and the widely used Vero E6 (African green monkey kidney) cell lines , Eckerle et al. 2014 ), among others. Culture, in vitro and ex vivo, has also been used to help determine cell tropism and identify potential natural hosts of the virus. MERS-CoV can infect a variety of human cell types and tissues in culture, including macrophages, fibroblasts, and endothelial cells (Scobey et al. 2013 , Tao et al. 2013 , Hin et al. 2016 . In an ex vivo study using human lung explants, MERS-CoV infected both alveolar epithelial cells and macrophages (Type II pneumocytes), with resulting alveolar damage (Hocke et al. 2013) .
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