Selected article for: "liver lung and study sequence"
Author: Schrom, Eva; Huber, Maja; Aneja, Manish; Dohmen, Christian; Emrich, Daniela; Geiger, Johannes; Hasenpusch, Günther; Herrmann-Janson, Annika; Kretzschmann, Verena; Mykhailyk, Olga; Pasewald, Tamara; Oak, Prajakta; Hilgendorff, Anne; Wohlleber, Dirk; Hoymann, Heinz-Gerd; Schaudien, Dirk; Plank, Christian; Rudolph, Carsten; Kubisch-Dohmen, Rebekka
Title: Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA
  • Document date: 2017_4_13
    • ID: tulmnb32_13
    Snippet: Re-establishment of a well-balanced RAS is repeatedly shown to have promising therapeutic effects in the treatment of liver and lung fibrosis. 5, 14, 15, 18, 19, [21] [22] [23] 46 These effects may be further enhanced by local translation of ACE2 in affected organs, which is feasible with the latest cmRNA technology. In this study, we designed an optimized sequence of chemically modified ACE2 mRNA that leads to prominent ACE2 protein translation .....
    Document: Re-establishment of a well-balanced RAS is repeatedly shown to have promising therapeutic effects in the treatment of liver and lung fibrosis. 5, 14, 15, 18, 19, [21] [22] [23] 46 These effects may be further enhanced by local translation of ACE2 in affected organs, which is feasible with the latest cmRNA technology. In this study, we designed an optimized sequence of chemically modified ACE2 mRNA that leads to prominent ACE2 protein translation and activity in vitro and in vivo.

    Search related documents:
    Co phrase search for related documents
    • cmrna technology and lung fibrosis liver: 1
    • cmrna technology and protein translation: 1
    • local translation and protein translation: 1, 2
    • lung fibrosis and protein translation: 1, 2, 3, 4, 5, 6, 7
    • lung fibrosis and therapeutic effect: 1, 2, 3, 4, 5, 6, 7
    • lung fibrosis liver and protein translation: 1, 2, 3, 4, 5
    • lung fibrosis liver treatment and protein translation: 1, 2
    • optimized sequence and protein translation: 1, 2, 3, 4