Author: Dawson, Patrick; Malik, Mamunur Rahman; Parvez, Faruque; Morse, Stephen S.
Title: What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review Document date: 2019_3_1
ID: yb54i1ne_86
Snippet: The search for the origins and natural hosts of MERS-CoV continues. Bat species across the world are known to host a wide variety of coronaviruses, including beta-coronaviruses (the genus to which MERS-CoV belongs) (Anthony et al. 2013 , Lelli et al. 2013 , Memish et al. 2013a , and bats tend to show greater coronavirus diversity than other mammals (Drexler et al. 2014 . Consequently, much research has focused on the possible origin of MERS-CoV i.....
Document: The search for the origins and natural hosts of MERS-CoV continues. Bat species across the world are known to host a wide variety of coronaviruses, including beta-coronaviruses (the genus to which MERS-CoV belongs) (Anthony et al. 2013 , Lelli et al. 2013 , Memish et al. 2013a , and bats tend to show greater coronavirus diversity than other mammals (Drexler et al. 2014 . Consequently, much research has focused on the possible origin of MERS-CoV in bats. Possibly further supporting this hypothesis, in bat cell lines MERS-CoV has been reported to replicate only in those cell lines that express DPP4, the functional human receptor for the virus, and not in bat cell lines lacking DPP4 expression , Cai et al. 2014 .
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