Author: Wang, Shiliang; Sundaram, Jaideep P.; Stockwell, Timothy B.
Title: VIGOR extended to annotate genomes for additional 12 different viruses Document date: 2012_6_4
ID: wd3ir3wg_4
Snippet: Universal gene prediction programs, such as FgenesV (www.softberry.com) and Zcurve_V (1) , are available for public use. However, accurate detection of the complex gene features is a major hurdle for these universal gene prediction tools. Therefore, species-specific gene prediction programs have been developed to conduct the gene calling for specific viral genomes. For example, FLAN was developed at NCBI to annotate influenza viral genomes (2) . .....
Document: Universal gene prediction programs, such as FgenesV (www.softberry.com) and Zcurve_V (1) , are available for public use. However, accurate detection of the complex gene features is a major hurdle for these universal gene prediction tools. Therefore, species-specific gene prediction programs have been developed to conduct the gene calling for specific viral genomes. For example, FLAN was developed at NCBI to annotate influenza viral genomes (2) . In order to efficiently validate genome sequence data and accurately annotate the viral genomes sequenced by MSC, a homology-based viral gene prediction program called VIGOR (Viral Genome ORF Reader, http://www.jcvi .org/vigor) was developed at J. Craig Venter Institute (JCVI) for influenza virus, coronavirus, SARS coronavirus, rhinovirus and rotavirus (3) .
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