Author: Rahaman, Jordon; Siltberg-Liberles, Jessica
Title: Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses Document date: 2016_11_9
ID: pygykil7_21
Snippet: NSP12 is often used as a measure for newly identified coronaviruses. According to the International Committee of Taxonomy of Viruses, a major criterion in determining if a coronavirus is considered novel is pairwise sequence identity below 90% for NSP12 in all comparisons to previously known coronaviruses (Bermingham et al. 2012) . Four main clades, alphacoronavirus, betacoronavirus, gammacoronavirus, and deltacoronavirus ( fig. 1) , are identifi.....
Document: NSP12 is often used as a measure for newly identified coronaviruses. According to the International Committee of Taxonomy of Viruses, a major criterion in determining if a coronavirus is considered novel is pairwise sequence identity below 90% for NSP12 in all comparisons to previously known coronaviruses (Bermingham et al. 2012) . Four main clades, alphacoronavirus, betacoronavirus, gammacoronavirus, and deltacoronavirus ( fig. 1) , are identified in agreement with the taxonomic classifications described by the ICTV (International Committee on Taxonomy of Viruses 2015). Coronaviruses not listed by the ICTV are assumed to be a part of the clade in which representatives with known classifications are situated in our NSP12 phylogeny.
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