Selected article for: "disease progression and immune response"
Author: D’Anna, Silvestro Ennio; Balbi, Bruno; Cappello, Francesco; Carone, Mauro; Di Stefano, Antonino
Title: Bacterial–viral load and the immune response in stable and exacerbated COPD: significance and therapeutic prospects
  • Document date: 2016_3_1
    • ID: qo3nejo9_24
    Snippet: COPD is an illness characterized by an abnormal inflammatory response of the lung. The inflammatory cell infiltration in the airways of these patients varies according to the stage of the disease. Recent findings show that the immune response is impaired in the COPD lung. 61 The microbiome in the airways of COPD patients is altered with increasing disease severity, and during the exacerbation process. Alterations of the normal bacterial populatio.....
    Document: COPD is an illness characterized by an abnormal inflammatory response of the lung. The inflammatory cell infiltration in the airways of these patients varies according to the stage of the disease. Recent findings show that the immune response is impaired in the COPD lung. 61 The microbiome in the airways of COPD patients is altered with increasing disease severity, and during the exacerbation process. Alterations of the normal bacterial populations in COPD patients with a reduction of bacterial variety are associated with an increased risk of exacerbation and severity, and bacteria and viruses play a pivotal causal role in COPD exacerbations and disease progression. Stable COPD patients can harbor respiratory viruses in their airways. Bacteria and viruses in the lungs could play a role in maintaining the inflammatory state in COPD patients during the stable phase. There is evidence that the bacterial and viral loads in the airways of stable COPD are directly correlated to the airways inflammation. Some studies evidence that some bacterial phyla such as Proteobacteria are more capable of stimulating inflammation in the airways of COPD patients.

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