Selected article for: "mRNA translation and RNA synthesis"
Author: Stenglein, Mark D.; Jacobson, Elliott R.; Wozniak, Edward J.; Wellehan, James F. X.; Kincaid, Anne; Gordon, Marcus; Porter, Brian F.; Baumgartner, Wes; Stahl, Scott; Kelley, Karen; Towner, Jonathan S.; DeRisi, Joseph L.
Title: Ball Python Nidovirus: a Candidate Etiologic Agent for Severe Respiratory Disease in Python regius
  • Document date: 2014_9_9
    • ID: rb3qdunj_25
    Snippet: Molecular characterization of subgenomic RNAs. Nidoviruses generate subgenomic mRNA species (sgRNAs) that are competent for the translation of the downstream 3= ORFs. In most of these viruses, these subgenomic mRNAs share 5= and 3= terminal sequences with the genomic RNA and are transcribed from minus-strand templates that are produced by a process termed discontinuous RNA synthesis (1, 2, 54) . In fact, the prefix "nido" refers to the nested nat.....
    Document: Molecular characterization of subgenomic RNAs. Nidoviruses generate subgenomic mRNA species (sgRNAs) that are competent for the translation of the downstream 3= ORFs. In most of these viruses, these subgenomic mRNAs share 5= and 3= terminal sequences with the genomic RNA and are transcribed from minus-strand templates that are produced by a process termed discontinuous RNA synthesis (1, 2, 54) . In fact, the prefix "nido" refers to the nested nature of these RNA species. In our deepsequencing data sets, we detected pairs of reads where the first read mapped to the 5= UTR and the second read mapped near the beginning of the downstream ORFs, suggesting that this virus might also generate sgRNA species by a similar process.

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