Author: Lu, Yan; Jiang, Yun; Ling, Lijun; Zhang, Yunyi; Li, Hong; Chen, Daofeng
Title: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities Document date: 2017_12_8
ID: q4r36tpw_35
Snippet: Histopathological findings of lung tissues with H&E staining showed clear pulmonary structure and little cellular influx in the Sham group, whereas the ALI animals exhibited severe lung injury, including marked interstitial edema, septal thickening, hemorrhage and inflammatory cell infiltration (Fig. 3A) . Prednisone was effective in suppressing lung damage. Administration of CHCP (50 mg/kg and 100 mg/kg) significantly attenuated the neutrophil a.....
Document: Histopathological findings of lung tissues with H&E staining showed clear pulmonary structure and little cellular influx in the Sham group, whereas the ALI animals exhibited severe lung injury, including marked interstitial edema, septal thickening, hemorrhage and inflammatory cell infiltration (Fig. 3A) . Prednisone was effective in suppressing lung damage. Administration of CHCP (50 mg/kg and 100 mg/kg) significantly attenuated the neutrophil accumulation, alveolar wall thickening, and intra-alveolar exudation. However, serious pulmonary inflammation was still seen in the low-dose group of CHCP (25 mg/kg). The above results were confirmed by the total lung injury scores listed in Table 2 .
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