Author: Sun, Ying; Xiao, ShaoBo; Wang, Dang; Luo, Rui; Li, Bin; Chen, HuanChun; Fang, LiuRong
Title: Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells Document date: 2011_12_16
ID: zrsnahi7_34
Snippet: To further determine the effect of cholesterol depletion Figure 4B , the amount of PRRSV genomes expressed in cells infected with released virus from MβCD-treated cells was approximately 10.6% of that in cells infected with released virus from mock-treated cells, and cholesterol replenishment partially counteracted this effect. These findings indicate that the infectivity of virus released from MβCD-treated cells was decreased compared with tho.....
Document: To further determine the effect of cholesterol depletion Figure 4B , the amount of PRRSV genomes expressed in cells infected with released virus from MβCD-treated cells was approximately 10.6% of that in cells infected with released virus from mock-treated cells, and cholesterol replenishment partially counteracted this effect. These findings indicate that the infectivity of virus released from MβCD-treated cells was decreased compared with those released from MβCD-cholesterol-treated and mock-treated cells. According to these data, we can conclude that MβCD treatment caused an enhancement of virus particle released from infected cells but the infectivity of released viruses was decreased by this treatment.
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