Author: Sun, Ying; Xiao, ShaoBo; Wang, Dang; Luo, Rui; Li, Bin; Chen, HuanChun; Fang, LiuRong
Title: Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells Document date: 2011_12_16
ID: zrsnahi7_38
Snippet: A previous study demonstrated that the entry of Equine arteritis virus, another member of Arteriviridae, could also be inhibited by cholesterol depletion, and virus entry requires plasma membrane cholesterol [30] . In the current study, we examined the effect of plasma membrane cholesterol on PRRSV attachment and penetration, the two stages of virus entry. We found that cholesterol mainly affects virus attachment, rather than penetration. It was .....
Document: A previous study demonstrated that the entry of Equine arteritis virus, another member of Arteriviridae, could also be inhibited by cholesterol depletion, and virus entry requires plasma membrane cholesterol [30] . In the current study, we examined the effect of plasma membrane cholesterol on PRRSV attachment and penetration, the two stages of virus entry. We found that cholesterol mainly affects virus attachment, rather than penetration. It was reported that PRRSV enters porcine alveolar macrophages (PAMs) via receptor-mediated endocytic vesicles and the low pH-dependent endocytic pathway [11] . Thus, it is possible that the effect of plasma membrane cholesterol on PRRSV entry into MARC-145 cell is also due to its influence on the endocytosis process.
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