Author: Maceyka, Michael; Machamer, Carolyn E.
Title: Ceramide Accumulation Uncovers a Cycling Pathway for the cis-Golgi Network Marker, Infectious Bronchitis Virus M Protein Document date: 1997_12_15
ID: wekvet6f_29
Snippet: Implicit in both models is the idea that IBV M contains retrieval information. PDMP-induced ER redistribution was also observed for ERGIC-53, a dilysine-containing IC marker known to cycle through the ER (Lippincott-Schwartz et al., 1990; Schindler et al., 1993) . Double-label immunoelectron microscopy in HeLa cells showed that the distri-bution of ERGIC-53 and IBV M overlapped significantly, though not completely (Sodeik et al., 1993) . This sug.....
Document: Implicit in both models is the idea that IBV M contains retrieval information. PDMP-induced ER redistribution was also observed for ERGIC-53, a dilysine-containing IC marker known to cycle through the ER (Lippincott-Schwartz et al., 1990; Schindler et al., 1993) . Double-label immunoelectron microscopy in HeLa cells showed that the distri-bution of ERGIC-53 and IBV M overlapped significantly, though not completely (Sodeik et al., 1993) . This suggests that IBV M may in part use the same, as yet unknown, cellular machinery used by IC proteins to maintain its steadystate localization. Using deletion mutants and chimeric molecules, dissection of IBV M retention and retrieval information should be possible using PDMP as a tool. The pathway followed by IBV M during retrieval will also be important to decipher. Experiments in nontreated cells suggest that the protein may move through later Golgi compartments even though its steady-state distribution is the CGN, because its oligosaccharides are slowly processed (Machamer et al., 1990) .
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