2017 ACVIM Forum Research Abstract Program

A total of 205 cats were identified in the search; 167 were ineligible and 38 met inclusion criteria. Of the 38 included cats, 16 were given PGT, 11 were given PGP, and 11 were given PCG. 5/ 38 had to change the dose of supplement, and 5/38 changed the supplement type. Dosing ranged from 0.21 -1.6 mEq/kg (49 -374.4 mg/kg) for PGT, 0.25 mEq/kg (59 -347 mg/kg) for PGP, and 0.04 -1.41 mEq/kg (4 -144 mg/kg) for PCG. 36/38 cats had an increase in potassium after supplementation (14/16 for PGT, 11/11 for PGP, and 11/11 for PCG). 34/38 cats had an increase to within the potassium reference range (13/16 for PGT, 10/11 for PGP, and 11/11 for PCG). 24/38 cats had an increase in potassium to > 4 mEq/L (8/16 for PGT, 8/11 for PGP, and 8/11 for PCG). Pre-supplementation potassium mean +/SD for PGT was 3.3 + /-0.5 and 4.1 + /-0.6 post-supplementation. Pre-supplementation potassium mean +/SD for PGP was 3.3 + /-0.4 and 4.2 + /-0.7 post-supplementation. Pre-supplementation potassium mean +/SD for PCG was 3.3 + /-0.2 and 4.1 + /-0.4 post-supplementation. There was a statistically significant difference in serum potassium post supplementation for all three medications: PGT (P = 0.0001), PGP (P = 0.001), PCG (P = 0.001). There was a positive correlation between PGT dose and change in potassium levels (P = 0.04), but no significant correlation for PGP or PCG. There was no significant difference between pre and post supplementation serum bicarbonate nor a correlation between potassium supplement dose and serum bicarbonate level. There was not enough data to assess effect on urine pH.