Author: Paquin, Ashley; Onabajo, Olusegun O.; Tang, Wei; Prokunina-Olsson, Ludmila
Title: Comparative Functional Analysis of 12 Mammalian IFN-?4 Orthologs Document date: 2016_1_1
ID: sqxrwgif_6
Snippet: Previously, based on available genomic sequences, IFN-l4 was predicted to exist in a number of mammals. Analysis of IFN-l4 protein sequences from 13 mammalian species showed evidence of purifying selection, which is a process of eliminating genetic changes that cause amino acid substitutions while retaining neutral (synonymous) variations (Key and others 2014) . This suggests that IFN-l4 is functionally important across species and evolutionary f.....
Document: Previously, based on available genomic sequences, IFN-l4 was predicted to exist in a number of mammals. Analysis of IFN-l4 protein sequences from 13 mammalian species showed evidence of purifying selection, which is a process of eliminating genetic changes that cause amino acid substitutions while retaining neutral (synonymous) variations (Key and others 2014) . This suggests that IFN-l4 is functionally important across species and evolutionary forces protect it from significant changes.
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