Author: Jabado, Omar J.; Liu, Yang; Conlan, Sean; Quan, P. Lan; Hegyi, Hédi; Lussier, Yves; Briese, Thomas; Palacios, Gustavo; Lipkin, W. I.
Title: Comprehensive viral oligonucleotide probe design using conserved protein regions Document date: 2007_12_13
ID: xfzhn1n1_38
Snippet: A second application of this design method is viral expression profiling. Insights into the replication cycle, host evasion and virulence factors may be obtained by monitoring viral transcript levels during infection. To this end, arrays could be synthesized that combine probes for a single viral family and all host genes. Because the viral probe sets generated by our method account for known variants across all genes, a variety of strains could .....
Document: A second application of this design method is viral expression profiling. Insights into the replication cycle, host evasion and virulence factors may be obtained by monitoring viral transcript levels during infection. To this end, arrays could be synthesized that combine probes for a single viral family and all host genes. Because the viral probe sets generated by our method account for known variants across all genes, a variety of strains could be profiled with a single array. This would provide a unique experimental platform for investigating virus biology, while minimizing fabrication cost and simplifying analysis.
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