Selected article for: "host pathogen and immune response"
Author: Lemaire, D.; Barbosa, T.; Rihet, P.
Title: Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
  • Document date: 2011_10_28
    • ID: q2y7fewk_16
    Snippet: In fact, despite the amount of available data about the genome of pathogens and the human genome, the genes, molecules, and mechanisms involved in pathogen virulence or in host defense are still not clear. Understanding the mechanisms of microbial infections and the immune response against them remains a major challenge in vaccine development. This could explain why relatively slow progress has been made in the development of new efficient vaccin.....
    Document: In fact, despite the amount of available data about the genome of pathogens and the human genome, the genes, molecules, and mechanisms involved in pathogen virulence or in host defense are still not clear. Understanding the mechanisms of microbial infections and the immune response against them remains a major challenge in vaccine development. This could explain why relatively slow progress has been made in the development of new efficient vaccines in spite of the emergence of high-throughput sequencing technologies and advances in bioinformatics.

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