Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis

Hasegawa, Daisuke; Ohnishi, Yumi; Koyama, Eiji; Matsunaga, Satoru; Ohtani, Shouhei; Nakanishi, Akio; Shiga, Takanori; Chambers, James K.; Uchida, Kazuyuki; Yokoi, Norihiko; Fukata, Yuko; Fukata, Masaki

and feline coronavirus and Toxoplasma gondii titers were 1 : 100 and <1 : 8, respectively. In addition, RT-PCR of Borna disease virus using a serum sample was negative. The heart rate was around 200 rpm, and the mean blood pressure was 95-100 mm Hg. Thoracic and abdominal X-rays were normal. These clinical findings suggested the cat was in postictal state, in nonconvulsive status epilepticus, or extreme sensitivity to the adverse effects of PB. Phenobarbital was discontinued, and zonisamide (ZNS; 4.6 mg/kg PO q12h), meloxicam (0.3 mg/kg SC q24h), ampicillin (25 mg/kg IV q12h), and IV fluid therapy with glycyrrhizin and glutathione were administered. Two days later (day 7), seizures were under control, and the above-mentioned neurological findings and temperature had recovered. A magnetic resonance imaging (MRI) (0.4 Tesla Aperto; Hitachi, Japan) of the head was performed on day 8, which revealed bilateral hippocampal swelling with T2-weighted/fluid-attenuated inversion recovery (FLAIR) hyperintensity and T1-weighted hypointensity that showed strong contrast enhancement after IV administration of gadodiamide (0.2 mL/kg; Omniscan, Daiichi-Sankyo, Japan) on transverse ( Figure 1 ) and dorsal planes.