Author: DOKI, Tomoyoshi; TAKANO, Tomomi; HOHDATSU, Tsutomu
Title: Development of a mouse-feline chimeric antibody against feline tumor necrosis factor-alpha Document date: 2016_6_4
ID: y0x0quha_5
Snippet: In the present study, we prepared mouse-feline chimeric mAb (chimeric mAb 2-4), in which the variable region of the previously reported anti-fTNF-alpha mAb 2-4 was fused to the feline antibody constant region, and confirmed its fTNF-alpha neutralization activity. In addition, purified mouse mAb 2-4 and chimeric mAb 2-4 were repeatedly administered to cats to investigate the changes in ability to induce a feline anti-mouse antibody response......
Document: In the present study, we prepared mouse-feline chimeric mAb (chimeric mAb 2-4), in which the variable region of the previously reported anti-fTNF-alpha mAb 2-4 was fused to the feline antibody constant region, and confirmed its fTNF-alpha neutralization activity. In addition, purified mouse mAb 2-4 and chimeric mAb 2-4 were repeatedly administered to cats to investigate the changes in ability to induce a feline anti-mouse antibody response.
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