Selected article for: "bioenergetic profile and glycolytic enzyme"
Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments
  • Document date: 2018_6_5
    • ID: ltb6l5xz_48
    Snippet: Based on strong cell-level evidence from this study and prior work, as well as decreases in glycolytic enzyme activity, we generated a schizophrenia bioenergetic profile consisting of 6 functionally related genes (14, 15, 18) . These 6 genes ("seed genes") are strong glycolysis regulators and critical steps in the glycolytic pathway. The 6 seed genes in our profile were used for lookup replication studies, iLINCS clustering, and iLINCS connectivi.....
    Document: Based on strong cell-level evidence from this study and prior work, as well as decreases in glycolytic enzyme activity, we generated a schizophrenia bioenergetic profile consisting of 6 functionally related genes (14, 15, 18) . These 6 genes ("seed genes") are strong glycolysis regulators and critical steps in the glycolytic pathway. The 6 seed genes in our profile were used for lookup replication studies, iLINCS clustering, and iLINCS connectivity (drug discovery) analyses.

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