Title: Development of graft-vs.-host disease-like syndrome in cyclosporine- treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity Document date: 1985_4_1
ID: rqggh4y2_28
Snippet: Our studies confirm the observations of Glazier et al. (15) that CsA treatment of rats receiving syngeneic marrow transplants result in the consistent development of a syndrome indistinguishable from GVHD, a syndrome which may be a generalized autoimmune phenomena. The target organs in syngeneic GVHD, as well as the histologic damage seen is comparable to GVHD following ailogeneic bone marrow transplantation (15, 21) ......
Document: Our studies confirm the observations of Glazier et al. (15) that CsA treatment of rats receiving syngeneic marrow transplants result in the consistent development of a syndrome indistinguishable from GVHD, a syndrome which may be a generalized autoimmune phenomena. The target organs in syngeneic GVHD, as well as the histologic damage seen is comparable to GVHD following ailogeneic bone marrow transplantation (15, 21) .
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