Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_753
Snippet: All components of the HPAA were activated in most critically ill foals. Some septic foals demonstrated HPAA dysfunction with hypocortisolemia as well as ACTH, and CRH insufficiency. High CRH/ACTH ratio in septic foals with hypocortisolemia suggested the pituitary dysfunction in addition to adrenocortical insufficiency. Hyperinsulinemia and insulin resistance are associated conditions in horses and insulin secretion increases as tissue insulin sen.....
Document: All components of the HPAA were activated in most critically ill foals. Some septic foals demonstrated HPAA dysfunction with hypocortisolemia as well as ACTH, and CRH insufficiency. High CRH/ACTH ratio in septic foals with hypocortisolemia suggested the pituitary dysfunction in addition to adrenocortical insufficiency. Hyperinsulinemia and insulin resistance are associated conditions in horses and insulin secretion increases as tissue insulin sensitivity decreases. We hypothesized that insulin-resistant (IR) horses would have increased insulin staining of pancreatic islets when compared to insulin-sensitive (IS) horses.
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