Selected article for: "CV variation coefficient and dilution linearity"
Title: 2017 ACVIM Forum Research Abstract Program
  • Document date: 2017_6_15
    • ID: ri2w5iby_800
    Snippet: Lithium chloride was administered as a 0.15 mmol/kg bwt IV bolus. Lithium concentrations were measured at times À30, À15, 0 (pre LiCl administration), 2.5, 5, 10, 20, 40 min and 1, 2, 4, 8, 12, 24, and 48 h (post LiCl administration) in healthy adult horses (n = 8). Performance outcomes of the SEA were assessed using the following criteria: linearity-of-dilution, inter-day coefficient of variation (CV), and spike-and-recovery. The two methods (.....
    Document: Lithium chloride was administered as a 0.15 mmol/kg bwt IV bolus. Lithium concentrations were measured at times À30, À15, 0 (pre LiCl administration), 2.5, 5, 10, 20, 40 min and 1, 2, 4, 8, 12, 24, and 48 h (post LiCl administration) in healthy adult horses (n = 8). Performance outcomes of the SEA were assessed using the following criteria: linearity-of-dilution, inter-day coefficient of variation (CV), and spike-and-recovery. The two methods (SEA and ICP-MS) of plasma Li + concentration measurement were compared for agreement. Pharmacokinetic parameters were determined based on the reference ICP-MS data.

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