2017 ACVIM Forum Research Abstract Program

Thirty-one horses with fever (rectal temperature ≥ 102.0°F) from naturally occurring disease were randomized to two groups. Fifteen horses were treated with a single dose of 30 mg/kg dipyrone intravenously (IV), and sixteen horses were treated with a single dose of saline (placebo) IV. Medications or procedures that may have affected the rectal temperature were prohibited. Rectal temperature was assessed six hours following treatment. Twentyfour hours following dose administration, febrile horses were crossed over to the other treatment group under the same procedures. Treatment response was defined as a temperature decrease of either ≥ 2.0°F from baseline or a return to normothermia (≤ 101.0°F) six hours after administration of dipyrone or saline. Statistical comparison between treatments was performed using the Fisher's Exact test, two-sided.