Author: Fang, H; Liu, A; Dahmen, U; Dirsch, O
Title: Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase Document date: 2013_6_27
ID: qmut89kb_16
Snippet: To the best of our knowledge, this is the first report showing that chloroquine has a dual effect in liver I/R injury. Following 60 or 90 min of warm ischemia, chloroquine treatment reduced liver injury at 0.5 and 6 h, but aggravated liver injury at 24 and 48 h after reperfusion. In the early phase (i.e., 0-6 h after reperfusion), the protective effect of chloroquine treatment was associated with a modulation of MAP kinase activation, inhibition .....
Document: To the best of our knowledge, this is the first report showing that chloroquine has a dual effect in liver I/R injury. Following 60 or 90 min of warm ischemia, chloroquine treatment reduced liver injury at 0.5 and 6 h, but aggravated liver injury at 24 and 48 h after reperfusion. In the early phase (i.e., 0-6 h after reperfusion), the protective effect of chloroquine treatment was associated with a modulation of MAP kinase activation, inhibition of HMGB1 release and reduction of inflammatory cytokine production. In contrast, in the late phase of reperfusion (i.e., 24-48 h after reperfusion), chloroquine treatment was associated with an aggravation of liver injury, an inhibition of autophagy and an induction of apoptosis.
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