Author: Lee, Seung Heon; Yang, Dong-Kun; Kim, Ha-Hyun; Cho, In-Soo
Title: Efficacy of inactivated variant porcine epidemic diarrhea virus vaccines in growing pigs Document date: 2018_1_29
ID: w643jf90_31
Snippet: Adaptation of viruses to cell culture passaging has been used to alter the mechanism of viral replication [21] . For instance, wild-type hepatitis A virus (HAV) produces a low yield of progeny virus due to its low replication capacity, but a cellculture-adapted HAV variant generated by repeated passaging produces higher titers of infectious viral particles [22] . A comparative study in which growing pigs were vaccinated with 10 6.0 to 10 8.0 TCID.....
Document: Adaptation of viruses to cell culture passaging has been used to alter the mechanism of viral replication [21] . For instance, wild-type hepatitis A virus (HAV) produces a low yield of progeny virus due to its low replication capacity, but a cellculture-adapted HAV variant generated by repeated passaging produces higher titers of infectious viral particles [22] . A comparative study in which growing pigs were vaccinated with 10 6.0 to 10 8.0 TCID50/mL inactivated PEDV vaccine reported that the humoral immune response increased with an increase in the viral titer inoculated [23] . Therefore, cell culture-adapted viral variants that yield higher titers should be used in the development of inactivated viral vaccines.
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