Author: Jin, Xi; Lian, Jiang-Shan; Hu, Jian-Hua; Gao, Jianguo; Zheng, Lin; Zhang, Yi-Min; Hao, Shao-Rui; Jia, Hong-Yu; Cai, Huan; Zhang, Xiao-Li; Yu, Guo-Dong; Xu, Kai-Jin; Wang, Xiao-Yan; Gu, Jue-Qing; Zhang, Shan-Yan; Ye, Chan-Yuan; Jin, Ci-Liang; Lu, Ying-Feng; Yu, Xia; Yu, Xiao-Peng; Huang, Jian-Rong; Xu, Kang-Li; Ni, Qin; Yu, Cheng-Bo; Zhu, Biao; Li, Yong-Tao; Liu, Jun; Zhao, Hong; Zhang, Xuan; Yu, Liang; Guo, Yong-Zheng; Su, Jun-Wei; Tao, Jing-Jing; Lang, Guan-Jing; Wu, Xiao-Xin; Wu, Wen-Rui; Qv, Ting-Ting; Xiang, Dai-Rong; Yi, Ping; Shi, Ding; Chen, Yanfei; Ren, Yue; Qiu, Yun-Qing; Li, Lan-Juan; Sheng, Jifang; Yang, Yida
Title: Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Document date: 2020_3_24
ID: zph6r4il_17
Snippet: Gene sequences of SARS (AAS00003.1 and AY278489.2) and Wuhan-Hu-1 (MN908947.3) were obtained from the NCBI viral genome database (https://www. ncbi. nlm. nih. gov/). ZJ01 was separated and named from a Zhejiang patient (online supplementary material-ZJ01 sequence). SRAMP (http://www. cuilab. cn/ sramp) was used to analyse gene sequences and predict post-transcriptional methylation (N6-methyladenosine) modification sites. According to the results,.....
Document: Gene sequences of SARS (AAS00003.1 and AY278489.2) and Wuhan-Hu-1 (MN908947.3) were obtained from the NCBI viral genome database (https://www. ncbi. nlm. nih. gov/). ZJ01 was separated and named from a Zhejiang patient (online supplementary material-ZJ01 sequence). SRAMP (http://www. cuilab. cn/ sramp) was used to analyse gene sequences and predict post-transcriptional methylation (N6-methyladenosine) modification sites. According to the results, the relevant predicted m 6 A sites can be divided into four levels: very high, high, medium and low confidence. Multalin (http:// multalin. toulouse. inra. fr/ multalin/ multalin. html) was used to compare the differences among these sequences. The SWISS-MODEL online server (https:// swissmodel. expasy. org/) was used to reconstruct the three-dimensional structure of proteins according to gene or amino sequence. The Poisson-Boltzmann equation can be used to calculate the electrostatic behaviour of S protein in aqueous solution through the vacuum electrostatics function of PyMol. Further analysis of the power of the protein model showed a difference in the electrostatic power distribution on the protein surface of the three virus strains.
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