Selected article for: "cap structure and cellular mRNA"
Author: Jin, Xi; Lian, Jiang-Shan; Hu, Jian-Hua; Gao, Jianguo; Zheng, Lin; Zhang, Yi-Min; Hao, Shao-Rui; Jia, Hong-Yu; Cai, Huan; Zhang, Xiao-Li; Yu, Guo-Dong; Xu, Kai-Jin; Wang, Xiao-Yan; Gu, Jue-Qing; Zhang, Shan-Yan; Ye, Chan-Yuan; Jin, Ci-Liang; Lu, Ying-Feng; Yu, Xia; Yu, Xiao-Peng; Huang, Jian-Rong; Xu, Kang-Li; Ni, Qin; Yu, Cheng-Bo; Zhu, Biao; Li, Yong-Tao; Liu, Jun; Zhao, Hong; Zhang, Xuan; Yu, Liang; Guo, Yong-Zheng; Su, Jun-Wei; Tao, Jing-Jing; Lang, Guan-Jing; Wu, Xiao-Xin; Wu, Wen-Rui; Qv, Ting-Ting; Xiang, Dai-Rong; Yi, Ping; Shi, Ding; Chen, Yanfei; Ren, Yue; Qiu, Yun-Qing; Li, Lan-Juan; Sheng, Jifang; Yang, Yida
Title: Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms
  • Document date: 2020_3_24
    • ID: zph6r4il_35
    Snippet: The change and mutation of SARS-CoV-2 are the basis of its variation in epidemiological and clinical features. Using in-depth bioinformatics analysis of the novel identified SARS-CoV-2 sequence from Zhejiang province, we identified many m 6 A methylation sites in the S1 segment of ZJ01 and S2 segment of SARS, indicating that the S proteins of the two viruses may have structural and functional differences due to m 6 A methylation. The addition of .....
    Document: The change and mutation of SARS-CoV-2 are the basis of its variation in epidemiological and clinical features. Using in-depth bioinformatics analysis of the novel identified SARS-CoV-2 sequence from Zhejiang province, we identified many m 6 A methylation sites in the S1 segment of ZJ01 and S2 segment of SARS, indicating that the S proteins of the two viruses may have structural and functional differences due to m 6 A methylation. The addition of chemical modifications is critical to many steps of mRNA processing and fate regulation, while the most abundant internal modification is N 6 -methyladenosin. 19 20 Given the wide prevalence of m 6 A modification on cellular mRNA, it is not surprising that a number of viruses contain m 6 A in their RNA. 21 22 The function of m 6 A methylation on viruses may be diverse with both proviral and antiviral roles. 23 24 Coronaviruses are enveloped RNA viruses containing the largest single-stranded, positive-sense RNA genome with a length between 25.5 and 32 kb. 25 In contrast to previously reported m 6 A modification in viruses, methylation at the N7 position of the 5'-cap structure of coronavirus RNA is commonly identified, which facilitates viral RNA escape recognition by the host innate immune system. 26 Therefore, our findings on the novel m 6 A methylation situation in SARS-CoV-2 may provide a novel mechanism for further study.

    Search related documents:
    Co phrase search for related documents
    • abundant internal modification and host escape recognition: 1
    • abundant internal modification and internal modification: 1, 2, 3, 4
    • bioinformatic analysis and immune system: 1, 2, 3, 4
    • bioinformatic analysis and immune system innate: 1, 2
    • chemical modification and immune system: 1
    • escape recognition and host escape recognition: 1, 2, 3, 4, 5, 6
    • escape recognition and immune system: 1, 2, 3, 4, 5, 6, 7, 8
    • escape recognition and immune system innate: 1, 2
    • escape recognition and internal modification: 1
    • host escape recognition and immune system innate: 1, 2