Author: Wassenaar, T.M.; Zou, Y.
Title: 2019_nCoV/SARS-CoV-2: rapid classification of betacoronaviruses and identification of Traditional Chinese Medicine as potential origin of zoonotic coronaviruses Document date: 2020_2_28
ID: rq9hmjsx_4
Snippet: Coronaviruses are divided into three genera: Alphacoronavirus, Betacoronavirus and Gammacoronavirus. SARS, MERS and 2019_nCoV are members of Betacoronavirus, which is divided into the subgenera Embecovirus, Hibecovirus, Merbecovirus, Nobecovirus and Sarbecovirus. All coronaviruses have a genome consisting of a positive-sense single-strand RNA molecule. A long polycystronic messenger is produced from this that codes for a number of proteins, some .....
Document: Coronaviruses are divided into three genera: Alphacoronavirus, Betacoronavirus and Gammacoronavirus. SARS, MERS and 2019_nCoV are members of Betacoronavirus, which is divided into the subgenera Embecovirus, Hibecovirus, Merbecovirus, Nobecovirus and Sarbecovirus. All coronaviruses have a genome consisting of a positive-sense single-strand RNA molecule. A long polycystronic messenger is produced from this that codes for a number of proteins, some of which are posttranslationally cleaved to produce smaller proteins (Cui et al. 2019) . Approximately two-thirds of the genome codes for a large open reading frame, often called 'orf 1ab' that undergoes a frame shift during translation, and whose product is processed into a number of smaller proteins, while a variable number of smaller open reading frames are located downstream of orf 1ab.
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