Selected article for: "CoV infection and severe patient"
Author: Cha, Ran-hui; Yang, Seung Hee; Moon, Kyung Chul; Joh, Joon-Sung; Lee, Ji Yeon; Shin, Hyoung-Shik; Kim, Dong Ki; Kim, Yon Su
Title: A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results
  • Document date: 2016_3_10
    • ID: rkwz1pwh_25
    Snippet: Although a few reports showed viral RNA in blood and urine samples, the relationship between the virus renal tropism and the physiopathology of the renal injury is not clear. And the independent renal viral replication and/or active urinary secretion of the virus remain unsolved. We can only say that localized MERS-CoV infection i.e., viral RNA detection in pharyngeal and tracheal swabs without systemic dissemination, results in favorable outcome.....
    Document: Although a few reports showed viral RNA in blood and urine samples, the relationship between the virus renal tropism and the physiopathology of the renal injury is not clear. And the independent renal viral replication and/or active urinary secretion of the virus remain unsolved. We can only say that localized MERS-CoV infection i.e., viral RNA detection in pharyngeal and tracheal swabs without systemic dissemination, results in favorable outcome. And viral dissemination through blood and urine under the impaired cytokine response leads to worse or fatal outcome (4). In the future, the viremic status and urinary virus excretion of the patient should be investigated especially in severe cases, and a timely kidney biopsy should be performed, with thorough precautions, to reveal the direct effects of MERS-CoV with respect complications. It could be helpful to monitor virus status in blood and urine samples from 2 weeks after the onset of illness.

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