Selected article for: "clinical study and organ injury"
Author: Yishan Zheng; Zhen Huang; Guoping Ying; Xia Zhang; Wei Ye; Zhiliang Hu; Chunmei Hu; Hongxia Wei; Yi Zeng; Yun Chi; Cong Cheng; Feishen Lin; Hu Lu; Lingyan Xiao; Yan Song; Chunming Wang; Yongxiang Yi; Lei Dong
Title: Comparative study of the lymphocyte change between COVID-19 and non-COVID-19 pneumonia cases suggesting uncontrolled inflammation might not be the main reason of tissue injury
  • Document date: 2020_2_23
    • ID: 5ge7ozpd_2
    Snippet: Analysis of clinical data available is in urgent demand for revealing the mechanisms of tissue damage and further devising more specific and efficient treatment strategies. 2 Compared with other beta coronaviruses, such as SARS-CoV and MERS-CoV, 2019-nCoV infection leads to significant differences in clinical symptoms, according to the latest studies [3] , including remarkably higher occurrence of non-fever patients, fewer upper respiratory and g.....
    Document: Analysis of clinical data available is in urgent demand for revealing the mechanisms of tissue damage and further devising more specific and efficient treatment strategies. 2 Compared with other beta coronaviruses, such as SARS-CoV and MERS-CoV, 2019-nCoV infection leads to significant differences in clinical symptoms, according to the latest studies [3] , including remarkably higher occurrence of non-fever patients, fewer upper respiratory and gastrointestinal symptoms, a different profile of increased blood cytokines, more frequent multi-organ injury, and lower death rate. [3] [4] [5] In this study, we analyzed the clinical and laboratory data of most of the 2019-nCoV-infected patients in the China city Nanjing, aimed at revealing the unique pathological features of COVID-19 cases in comparison with non-2019-nCoV-caused pneumonia cases. Importantly, through correlation analysis of the changes in blood cell subgroups and key blood biochemical indexes of tissue injury, we have discovered unexpected clues of the pathogenic process following 2019-nCoV infection, which may provide valuable information for designing efficient approaches of treatment.

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