Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_16
Snippet: In relation to the potential selection of AD genes for pathogen resistance (e.g., the concentration of the APOE4 allele in areas of high parasite burden), the 78 AD genes were also compared against a series of GWAS datasets related to general pathogen or protozoan diversity, viral diversity and the immune response to parasitic worms, across multiple human populations in different geographical locations. Such genes are likely to have been selected.....
Document: In relation to the potential selection of AD genes for pathogen resistance (e.g., the concentration of the APOE4 allele in areas of high parasite burden), the 78 AD genes were also compared against a series of GWAS datasets related to general pathogen or protozoan diversity, viral diversity and the immune response to parasitic worms, across multiple human populations in different geographical locations. Such genes are likely to have been selected for pathogen resistance [92] [93] [94] [95] .
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