Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_41
Snippet: A⤠is an antibacterial, antifungal, and antiviral agent. It has been shown that it binds to C. albicans and S. typhimurium [47] and presumably to other microbes. Such microbes may well have sequestered host proteins specific to their particular life cycles during their passage to the cell, and this would partly explain the interactome enrichment. In addition to the plaque proteins relating to pathogen life cycles (for example receptor binding, .....
Document: A⤠is an antibacterial, antifungal, and antiviral agent. It has been shown that it binds to C. albicans and S. typhimurium [47] and presumably to other microbes. Such microbes may well have sequestered host proteins specific to their particular life cycles during their passage to the cell, and this would partly explain the interactome enrichment. In addition to the plaque proteins relating to pathogen life cycles (for example receptor binding, endocytosis, and transport between intracellular compartments or nuclear entry and subsequent translation in the case of HSV-1), the proteins found in plaques and tangles contain many related to the immune system, inflammation and autophagy, all of which play a general role in pathogen defense [84] [85] [86] as does Aâ¤.
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