Author: Hu, Song; Jiang, Li-Bin; Zou, Xiao-Jing; Yi, Wei; Tian, De-Ying
Title: Hepatitis B virus upregulates host expression of a-1,2-mannosidases via the PPARa pathway Document date: 2016_11_21
ID: w5m23ikh_21
Snippet: The expression levels of mannosidases were higher in AD38 cells than those in ND10 cells, which were in turn greater than those in G2.2.15 cells. To investigate the association between the expression of α-1,2mannosidase and virus secretion, we assessed virus secretion in the cell culture supernatants of various HBV cell lines. Among the three cell lines, AD38 without Tet showed the highest secretion of HBV-DNA (10 7.8 ± 0.1 IU/mL), HBeAg (21.9 .....
Document: The expression levels of mannosidases were higher in AD38 cells than those in ND10 cells, which were in turn greater than those in G2.2.15 cells. To investigate the association between the expression of α-1,2mannosidase and virus secretion, we assessed virus secretion in the cell culture supernatants of various HBV cell lines. Among the three cell lines, AD38 without Tet showed the highest secretion of HBV-DNA (10 7.8 ± 0.1 IU/mL), HBeAg (21.9 ± 0.8 NCU/mL), and HBsAg (87.5 ± 2.4 IU/mL) ( Figure 1C-E) . Further, the expression of α-1,2-mannosidase in all the cell lines was positively correlated with the expression of HBsAg ( Figure 1D ).
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