Author: Than, Thoa Thi; Jo, Eunji; Todt, Daniel; Nguyen, Phuong Hong; Steinmann, Jochen; Steinmann, Eike; Windisch, Marc P
Title: High Environmental Stability of Hepatitis B Virus and Inactivation Requirements for Chemical Biocides Document date: 2019_4_1
ID: y9ezh49z_3
Snippet: Owing to the lack of appropriate cell culture models susceptible to HBV infection, evidence-based guidelines on the prevention and management of occupational exposures are incomplete and have been based mainly on studies of duck hepatitis B virus (DHBV) as a surrogate virus [5] . Recently, the discovery of the Na + -taurocholate cotransporting polypeptide (NTCP) as a crucial HBV cell entry factor has opened the door to new avenues of investigatio.....
Document: Owing to the lack of appropriate cell culture models susceptible to HBV infection, evidence-based guidelines on the prevention and management of occupational exposures are incomplete and have been based mainly on studies of duck hepatitis B virus (DHBV) as a surrogate virus [5] . Recently, the discovery of the Na + -taurocholate cotransporting polypeptide (NTCP) as a crucial HBV cell entry factor has opened the door to new avenues of investigation, as NTCP-overexpressing hepatoma cells acquire susceptibility to HBV infections [6] . This system enabled us to systematically address the environmental stability of HBV at different temperatures ex vivo and its susceptibility to various types of alcohol and routinely used commercially available hand antiseptics. Furthermore, we tested hand hygiene formulations recommended by the World Health Organization (WHO) against HBV in a comparative analysis with other enveloped viruses. The results should be useful in defining rigorous disinfection protocols to prevent nosocomial and occupational transmission of HBV in the future.
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