Author: He, Cheng; Kong, Ling; Zhou, Lijuan; Xia, Jing; Wei, Haixia; Liu, Min; Peng, Hongjuan
Title: Host Cell Vimentin Restrains Toxoplasma gondii Invasion and Phosphorylation of Vimentin is Partially Regulated by Interaction with TgROP18 Document date: 2017_9_5
ID: z9mg639h_4
Snippet: ROP18, a serine-threonine kinase secreted by T. gondii rhoptries into the PV and host cytosol has emerged as a major virulence factor [23] ; however, the mechanisms by which this kinase modulates host factors to exert its pathogenic action remain poorly understood [24] . TgROP18 can target members of the mouse IFN-γ inducible large GTPases (immunity-related GTPases [IRGs]), such as Irgb6 [25, 26] , and phosphorylate human ATF6β [27] , to mediat.....
Document: ROP18, a serine-threonine kinase secreted by T. gondii rhoptries into the PV and host cytosol has emerged as a major virulence factor [23] ; however, the mechanisms by which this kinase modulates host factors to exert its pathogenic action remain poorly understood [24] . TgROP18 can target members of the mouse IFN-γ inducible large GTPases (immunity-related GTPases [IRGs]), such as Irgb6 [25, 26] , and phosphorylate human ATF6β [27] , to mediate its virulence during infection. Herein, we demonstrate that expression of host cell vimentin is restrained by Toxoplasma gondii invasion, and that vimentin interacts with and is phosphorylated byTgROP18.
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