Author: Seo, Sachiko; Waghmare, Alpana; Scott, Emily M; Xie, Hu; Kuypers, Jane M; Hackman, Robert C.; Campbell, Angela P.; Choi, Su-Mi; Leisenring, Wendy M.; Jerome, Keith R.; Englund, Janet A.; Boeckh, Michael
Title: Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality Document date: 2017_6_23
ID: t7qk6evo_28
Snippet: The study herein showed that patients who have HRV detected in the lower respiratory tract have similar outcomes to patients with LRI due to known pathogenic viruses such as RSV, PIV and influenza virus, even after excluding other potential bacterial, fungal and viral copathogens. Although the detection of HRV RNA by RT-PCR is not proof of ongoing viral replication, we were also able to detect replicating virus from the lung tissue of a subset of.....
Document: The study herein showed that patients who have HRV detected in the lower respiratory tract have similar outcomes to patients with LRI due to known pathogenic viruses such as RSV, PIV and influenza virus, even after excluding other potential bacterial, fungal and viral copathogens. Although the detection of HRV RNA by RT-PCR is not proof of ongoing viral replication, we were also able to detect replicating virus from the lung tissue of a subset of patients with a fatal outcome, thus demonstrating that these viruses were viable and potentially responsible for the pulmonary disease in these patients.
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