Author: Girardi, Erika; Chane-Woon-Ming, Béatrice; Messmer, Mélanie; Kaukinen, Pasi; Pfeffer, Sébastien
Title: Identification of RNase L-Dependent, 3'-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells Document date: 2013_11_19
ID: v6uc0ijw_39
Snippet: The enzyme responsible for the methylation of SINV RNA remains unknown. However, it has been reported that the alphavirus nsP2 protein contains a putative methyltransferase (MT)-like domain, similar to dengue virus NS5 MTase (55) . Although the activity of this domain has not been verified yet, nsP2-MTase mutant viruses exhibit a strong phenotype: negative-strand synthesis is continuous, and unstable viral replication complexes are produced. Surp.....
Document: The enzyme responsible for the methylation of SINV RNA remains unknown. However, it has been reported that the alphavirus nsP2 protein contains a putative methyltransferase (MT)-like domain, similar to dengue virus NS5 MTase (55) . Although the activity of this domain has not been verified yet, nsP2-MTase mutant viruses exhibit a strong phenotype: negative-strand synthesis is continuous, and unstable viral replication complexes are produced. Surprisingly, RNase L-deficient cells infected with SINV display the same phenotype, suggesting that the two proteins function in similar events (55) . For all these reasons, we propose that RNase L-dependent, 3=-modified small RNAs from SINV could be involved as intermediates in this mechanism.
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