Author: Abbas, Aymn Talat; El-Kafrawy, Sherif Aly; Sohrab, Sayed Sartaj; Azhar, Esam Ibraheem Ahmed
Title: IgY antibodies for the immunoprophylaxis and therapy of respiratory infections Document date: 2018_9_19
ID: xsfg7uth_23
Snippet: Tuberculosis is a major global concern in both human and animal populations. The disease is caused by a group of highly related intracellular pathogens, Mycobacterium tuberculosis complex (MTBC), that cause human morbidity and mortality worldwide. 114 Although a third of the world's population is latently infected with MTB, only 5-10% develop active tuberculosis (TB). 115 In 2016, TB was the leading cause of death, with about 1.3 million human de.....
Document: Tuberculosis is a major global concern in both human and animal populations. The disease is caused by a group of highly related intracellular pathogens, Mycobacterium tuberculosis complex (MTBC), that cause human morbidity and mortality worldwide. 114 Although a third of the world's population is latently infected with MTB, only 5-10% develop active tuberculosis (TB). 115 In 2016, TB was the leading cause of death, with about 1.3 million human deaths. 116 The combination of TB with HIV/AIDS and the development of multidrug-resistant strains have increased the disease burden. 117 Immunotherapy might present a new option for treating drug-resistant TB strains, with promising outcomes and better quality of life for patients.-118 Intramuscular immunization of Lohmann laying hens showed an increase of anti-MTBC IgY antibodies in egg yolk, with peak concentration at 4 weeks after immunization. The specific antibodies were persist 200 days after the last immunization. The study suggested that, specific anti-MTBC IgY could be an effective approach as immunotherapy of TB (Table 1) .
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