Author: Shif, Ilan; Bang, Frederik B.
Title: IN VITRO INTERACTION OF MOUSE HEPATITIS VIRUS AND MACROPHAGES FROM GENETICALLY RESISTANT MICE : II. BIOLOGICAL CHARACTERIZATION OF A VARIANT VIRUS MHV(C(3)H) ISOLATED FROM STOCKS OF MHV(PRI) Document date: 1970_3_31
ID: ygy9o4bj_25
Snippet: However, adaptation to a new host in this present instance involves an adaption to a strain of mice which differs in terms of susceptibility from the original host mouse (PRI) apparently by only one genetic locus. Thus, the change in virus which is necessary to overcome the genetic barrier to growth in resistant macrophages may also be a limited step, and therefore occurs much more readily. Furthermore, because of the apparent blocking effect of .....
Document: However, adaptation to a new host in this present instance involves an adaption to a strain of mice which differs in terms of susceptibility from the original host mouse (PRI) apparently by only one genetic locus. Thus, the change in virus which is necessary to overcome the genetic barrier to growth in resistant macrophages may also be a limited step, and therefore occurs much more readily. Furthermore, because of the apparent blocking effect of MHV(PRI) on the growth of MHV(C~H), it is not possible at the moment to know exactly when MHV(C3H) appears.
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