Author: Falzarano, Darryl; de Wit, Emmie; Martellaro, Cynthia; Callison, Julie; Munster, Vincent J.; Feldmann, Heinz
Title: Inhibition of novel ß coronavirus replication by a combination of interferon-a2b and ribavirin Document date: 2013_4_18
ID: tgngoea8_8
Snippet: Vero cells have been described as comparatively resistant to ribavirin, as they are inefficient at converting ribavirin into its mono-and tri-phosphate forms 19 . Therefore, we also assessed the sensitivity of hCoV-EMC/2012 to IFN-a2b and ribavirin in LLC-MK2 cells ( Figure 3A , B). Based on IC values, LLC-MK2 cells were more responsive to both IFN-a2b and ribavirin treatment (Table 1) . IFN-a2b, at the maximum concentration tested (2000 U/ml), r.....
Document: Vero cells have been described as comparatively resistant to ribavirin, as they are inefficient at converting ribavirin into its mono-and tri-phosphate forms 19 . Therefore, we also assessed the sensitivity of hCoV-EMC/2012 to IFN-a2b and ribavirin in LLC-MK2 cells ( Figure 3A , B). Based on IC values, LLC-MK2 cells were more responsive to both IFN-a2b and ribavirin treatment (Table 1) . IFN-a2b, at the maximum concentration tested (2000 U/ml), reduced infectious titers by 3.97-log (2.01-log reduction in genome copies). Ribavirin treatment, at 200 mg/ml or higher, reduced infectious virus below the detection threshold of 13.7 TCID 50 /ml.
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