Author: Uzoma, Ijeoma; Zhu, Heng
Title: Interactome Mapping: Using Protein Microarray Technology to Reconstruct Diverse Protein Networks Document date: 2013_1_17
ID: t96j8qt0_25
Snippet: The virus takes advantage of the SUMOylation system by encoding proteins that are SUMO modified and those that bind to SUMO [14] . As previously mentioned SUMO is involved in DDR, which is further supported by the finding that BGLF4 appears to interact with sites of DNA damage via SUMO binding, revealing an additional mechanism promoting EBV-mediated DDR and lytic replication. SUMO interaction is as important as the kinase activity for the functi.....
Document: The virus takes advantage of the SUMOylation system by encoding proteins that are SUMO modified and those that bind to SUMO [14] . As previously mentioned SUMO is involved in DDR, which is further supported by the finding that BGLF4 appears to interact with sites of DNA damage via SUMO binding, revealing an additional mechanism promoting EBV-mediated DDR and lytic replication. SUMO interaction is as important as the kinase activity for the function of BGLF4.
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