Selected article for: "high throughput and viral infection"
Author: Uzoma, Ijeoma; Zhu, Heng
Title: Interactome Mapping: Using Protein Microarray Technology to Reconstruct Diverse Protein Networks
  • Document date: 2013_1_17
    • ID: t96j8qt0_7
    Snippet: A solid understanding of the molecular mechanisms of biological functions requires systematic profiling of dynamic interactions between biomolecules. Processes such as transcriptional regulation, viral infection, numerous PTMs and protein-protein interactions account for a small fraction of the potential molecular interactions within a cell but highlight how fundamental these networks are for essential functions. High throughput technologies stri.....
    Document: A solid understanding of the molecular mechanisms of biological functions requires systematic profiling of dynamic interactions between biomolecules. Processes such as transcriptional regulation, viral infection, numerous PTMs and protein-protein interactions account for a small fraction of the potential molecular interactions within a cell but highlight how fundamental these networks are for essential functions. High throughput technologies strive to provide an unbiased platform for charting these relationships at the proteome and gen-ome scale. In this section we will review several studies that demonstrate the utility of protein microarrays in reconstructing interaction networks.

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