Selected article for: "hydrophobic basic stretch and membrane fusion"
Author: Rathore, Shailendra S.; Liu, Yinghui; Yu, Haijia; Wan, Chun; Lee, MyeongSeon; Yin, Qian; Stowell, Michael H.B.; Shen, Jingshi
Title: Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE
  • Document date: 2019_12_24
    • ID: pudp1eoo_14
    Snippet: The juxtamembrane motif of VAMP2 also contains a hydrophobic stretch (residues 88-93) buried in the nonpolar phase of the membrane bilayer . We observed that SNARE-Munc18-1-mediated liposome fusion was strongly inhibited when this hydrophobic stretch was deleted or mutated into alanines ( Figure 4B ). Thus, like the basic residues, the hydrophobic stretch is critical for the function of the juxtamembrane motif in membrane fusion......
    Document: The juxtamembrane motif of VAMP2 also contains a hydrophobic stretch (residues 88-93) buried in the nonpolar phase of the membrane bilayer . We observed that SNARE-Munc18-1-mediated liposome fusion was strongly inhibited when this hydrophobic stretch was deleted or mutated into alanines ( Figure 4B ). Thus, like the basic residues, the hydrophobic stretch is critical for the function of the juxtamembrane motif in membrane fusion.

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