Selected article for: "juxtamembrane motif and membrane fusion reaction"
Author: Rathore, Shailendra S.; Liu, Yinghui; Yu, Haijia; Wan, Chun; Lee, MyeongSeon; Yin, Qian; Stowell, Michael H.B.; Shen, Jingshi
Title: Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE
  • Document date: 2019_12_24
    • ID: pudp1eoo_23
    Snippet: Thus, the SNARE-Munc18-1-mediated fusion reaction is highly sensitive to linker insertions, indicating that the membrane-destabilizing juxtamembrane motif must be directly connected to the force-generating SNARE motif with minimal spacing. Interestingly, in vivo exocytosis also tolerated a two-residue insertion but was abrogated when longer linkers were introduced ( Figure 7C ; Deák et al., 2006; Kesavan et al., 2007) . The strong correlation of.....
    Document: Thus, the SNARE-Munc18-1-mediated fusion reaction is highly sensitive to linker insertions, indicating that the membrane-destabilizing juxtamembrane motif must be directly connected to the force-generating SNARE motif with minimal spacing. Interestingly, in vivo exocytosis also tolerated a two-residue insertion but was abrogated when longer linkers were introduced ( Figure 7C ; Deák et al., 2006; Kesavan et al., 2007) . The strong correlation of our biochemical data with genetic observations further supports the physiological relevance of the membrane-destabilizing function uncovered in this work.

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