Author: Parvez, Mohammad K.; Tabish Rehman, Md.; Alam, Perwez; Al-Dosari, Mohammed S.; Alqasoumi, Saleh I.; Alajmi, Mohammed F.
Title: Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study Document date: 2018_12_26
ID: xibqsjib_22
Snippet: The sequence of HBV Pol/RT (GenBank: AGA95798.1) was retrieved from NCBI database (https://www.ncbi.nlm.nih.gov/genbank/). The HBV amino acid residues 347-698 responsible for the Pol activity (Daga et al., 2010) was used as query to search protein database for the identification of a suitable template with known X-ray crystal structure. The X-ray crystal structure of geneticallyclose HIV-RT (PDB Id: 1RTD) was selected as template to model the HBV.....
Document: The sequence of HBV Pol/RT (GenBank: AGA95798.1) was retrieved from NCBI database (https://www.ncbi.nlm.nih.gov/genbank/). The HBV amino acid residues 347-698 responsible for the Pol activity (Daga et al., 2010) was used as query to search protein database for the identification of a suitable template with known X-ray crystal structure. The X-ray crystal structure of geneticallyclose HIV-RT (PDB Id: 1RTD) was selected as template to model the HBV Pol structure as reported previously (Huang et al., 1998) . Swiss model server was used for the prediction of threedimensional structure of HBV Pol (Arnold et al., 2006) . The quality of the predicted structure was validated by Ramachandran plot using RAMPAGE server (Lovell et al., 2003) .
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