Author: LI, Xunliang; LI, Pengchong; CAO, Liyan; BAI, Yunyun; CHEN, Huijie; LIU, He; REN, Xiaofeng; LI, Guangxing
Title: Porcine IL-12 plasmid as an adjuvant improves the cellular and humoral immune responses of DNA vaccine targeting transmissible gastroenteritis virus spike gene in a mouse model Document date: 2019_9_2
ID: rme6b022_41
Snippet: Th cells can differentiate into Th1 and Th2 through the secretion of different cytokines. Th1 cells are mostly influenced by IL-2 and IFN-γ and regulate cellular immune responses, while Th2 cells are mainly controlled by IL-10 and IL-4 and activate the humoral immune responses. The analyzes of specific antibodies and neutralizing antibodies revealed that pVAX1-(TGEV-S1) plus pVAX1-(pIL-12) and inactivated vaccine had similar effects on humoral i.....
Document: Th cells can differentiate into Th1 and Th2 through the secretion of different cytokines. Th1 cells are mostly influenced by IL-2 and IFN-γ and regulate cellular immune responses, while Th2 cells are mainly controlled by IL-10 and IL-4 and activate the humoral immune responses. The analyzes of specific antibodies and neutralizing antibodies revealed that pVAX1-(TGEV-S1) plus pVAX1-(pIL-12) and inactivated vaccine had similar effects on humoral immune response and developed a much stronger response than other treatments, including pVAX1-(TGEV-S1). The high titer of neutralizing antibody observed in the inactivated vaccine group was due to its more complex components. Interestingly, the pVAX1-(TGEV-S1) and pVAX1-(TGEV-S1) plus pVAX1-(pIL-12) immunized groups had different IFN-γ and IL-4 responses, suggesting that they activate different arms of the immune system [29] .
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