Author: Huo, Caiyun; Xiao, Jin; Xiao, Kai; Zou, Shumei; Wang, Ming; Qi, Peng; Liu, Tianlong; Hu, Yanxin
Title: Pre-Treatment with Zirconia Nanoparticles Reduces Inflammation Induced by the Pathogenic H5N1 Influenza Virus Document date: 2020_1_30
ID: wqzve7i5_3
Snippet: In the present study, a series of NPs were investigated with regard to particle size, surface charge, and composition for NP-mediated protection of animals from highly pathogenic avian influenza virus H5N1 infection. The results showed that ZrO 2 with optimal physical and chemical characteristics could reduce mouse mortality, alleviate respiratory pathological changes, and inhibit viral replication in the lungs of H5N1-infected mice. Treatment wi.....
Document: In the present study, a series of NPs were investigated with regard to particle size, surface charge, and composition for NP-mediated protection of animals from highly pathogenic avian influenza virus H5N1 infection. The results showed that ZrO 2 with optimal physical and chemical characteristics could reduce mouse mortality, alleviate respiratory pathological changes, and inhibit viral replication in the lungs of H5N1-infected mice. Treatment with ZrO 2 prior to influenza infection caused prompt initiation of the host antiviral response and alleviated the damage induced by cytokine storms during H5N1 infection. This is the first report of an in vivo antiviral effect of ZrO 2 against H5N1 infection, and provides a comprehensive and low-cost method for the protection of humans or animals against various viral infections.
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