Author: Dejnirattisai, Wanwisa; Webb, Andrew I.; Chan, Vera; Jumnainsong, Amonrat; Davidson, Andrew; Mongkolsapaya, Juthathip; Screaton, Gavin
Title: Lectin Switching During Dengue Virus Infection Document date: 2011_6_15
ID: qos9vu3r_4
Snippet: As dengue virus circulates between 2 hosts, humans and insects, it has to be adapted to replicate and infect both species. The majority of studies of dengue infection and tropism use viruses produced in insect cell lines such as C6/36 or mammalian tumor cell lines such as Vero cells. Infection of humans occurs in a stepwise fashion: initial infection of cells with insect virus, followed by sequential infection of cells by mammalian-produced virus.....
Document: As dengue virus circulates between 2 hosts, humans and insects, it has to be adapted to replicate and infect both species. The majority of studies of dengue infection and tropism use viruses produced in insect cell lines such as C6/36 or mammalian tumor cell lines such as Vero cells. Infection of humans occurs in a stepwise fashion: initial infection of cells with insect virus, followed by sequential infection of cells by mammalian-produced virus. We were interested to determine whether there were any differences in the tropism of viruses produced in primary nontransformed human cells.
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