Selected article for: "dengue infection and initial infection"
Author: Dejnirattisai, Wanwisa; Webb, Andrew I.; Chan, Vera; Jumnainsong, Amonrat; Davidson, Andrew; Mongkolsapaya, Juthathip; Screaton, Gavin
Title: Lectin Switching During Dengue Virus Infection
  • Document date: 2011_6_15
    • ID: qos9vu3r_43
    Snippet: We conclude that skin-resident DCs are a likely target for initial infection by dengue virus injected by the infecting mosquito; however, subsequent dissemination of the virus to monocytes and other cell types will no longer use DC-SIGN as a primary receptor and may rely in part on a shift to L-SIGN as the primary lectin receptor. The differential glycosylation of the DENV E protein during replication in primary mammalian cells suggests that stud.....
    Document: We conclude that skin-resident DCs are a likely target for initial infection by dengue virus injected by the infecting mosquito; however, subsequent dissemination of the virus to monocytes and other cell types will no longer use DC-SIGN as a primary receptor and may rely in part on a shift to L-SIGN as the primary lectin receptor. The differential glycosylation of the DENV E protein during replication in primary mammalian cells suggests that studies of virus tropism using virus prepared in insect cells or tumor cell lines should be interpreted with caution.

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