Author: Imai-Matsushima, Aki; Martin-Sancho, Laura; Karlas, Alexander; Imai, Seiichiro; Zoranovic, Tamara; Hocke, Andreas C.; Mollenkopf, Hans-Joachim; Berger, Hilmar; Meyer, Thomas F.
Title: Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies Document date: 2018_6_22
ID: vopbw1tl_2
Snippet: The human alveolar epithelium is lined with non-proliferative type I alveolar epithelial (AEI) cells specialized for gas exchange, and proliferative type II alveolar epithelial (AEII) cells, which produce surfactant proteins with essential roles during innate immune responses [1, 2] . AEII cells are targeted by various pathogens that cause life-threatening pneumonia, several of which have a zoonotic origin [3] . This includes influenza A virus (I.....
Document: The human alveolar epithelium is lined with non-proliferative type I alveolar epithelial (AEI) cells specialized for gas exchange, and proliferative type II alveolar epithelial (AEII) cells, which produce surfactant proteins with essential roles during innate immune responses [1, 2] . AEII cells are targeted by various pathogens that cause life-threatening pneumonia, several of which have a zoonotic origin [3] . This includes influenza A virus (IAV), whose natural reservoir is birds but which has undergone human adaptation causing serious pandemics [4] [5] [6] [7] [8] [9] . Comparative studies using available cell types to study IAV zoonosis, such as human lung adenocarcinoma cell line A549 and the chicken embryonic fibroblast cell line DF-1, are likely to confound species-, tissue-, and cell line-specific effects. Therefore, establishing human and avian primary cell models would enable more physiologically relevant comparison.
Search related documents:
Co phrase search for related documents- AEII cell and alveolar epithelial: 1, 2
- AEII cell and cell line: 1
- AEII cell and surfactant protein: 1, 2
- alveolar epithelial and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- alveolar epithelial and cell model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- alveolar epithelial and cell type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46
- alveolar epithelial and comparative study: 1
- alveolar epithelial and essential role: 1, 2, 3
- alveolar epithelial and gas exchange: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- alveolar epithelial and human alveolar epithelium: 1, 2
- alveolar epithelial and IAV virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- alveolar epithelial and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63
- alveolar epithelial and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- alveolar epithelial and natural reservoir: 1
- alveolar epithelial and pandemic cause: 1, 2, 3
- alveolar epithelial and primary cell model: 1
- alveolar epithelial and surfactant protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- available cell type and cell type: 1, 2, 3, 4, 5
Co phrase search for related documents, hyperlinks ordered by date